HOW DOES METHADONE HELP WITH ADDICTION - AN OVERVIEW

[sixty one] Like numerous other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, that is considerably less powerful being an opioid, is much more strong at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone incorporates a lower affi